Circulomes

Recent work from our group shows that the repertoire of circular DNA (or as we coined, the Circulome) varies as a function of tissue type and health and disease- even within the same individual. This important discovery highlights the powerful impact the Circulome can play as a fingerprint of disease. It is clear that technologies that can unbiasedly isolate all circular DNA from any biological source, in addition to highly sensitive and rigorous informatic toolkits that can detect the slightest shifts in the Circulome, are needed to define the Circulome. Such platforms are technologically challenging but absolutely necessary to detect the slightest shifts in the Circulome and attribute causal elements to specific disease at the earliest sign. Phinomics, with our highly experienced team, is at the forefront of these transformative efforts.

Cancer Application:

Phinomics is dedicated to unraveling the complex networks and regulatory circuits that drive cancer biology. This holistic approach not only enables the discovery of novel biomarkers and therapeutic targets but also establishes a foundation for precision medicine, equipping clinicians and researchers with unparalleled insights into the molecular basis of disease and empowering informed clinical decision-making.

We are poised to be the leader in circular-DNA-based precision medicine, employing these DNAs to advance human health and to fill a major gap in the current picture of human genome and disease.

 

In addition to our internal programs focused on early detection of cancer drivers & identification of new therapeutics, We have various pipelines ranging from immunogenomics, to microbiome and drug resistance.   

We are the only team with exclusive patented technologies and the unique capacity to unbiasedly isolate, characterize, sequence, and informatically analyze ALL circular elements (of all sequences, topologies, and sizes) and attribute specific diver circular DNAs to the pathology they are causing.