PHINOMICS
Defining the Circulome to
Solve Disease
Precision-targeted Medicine to conquer the world’s most intractable diseases.
Your genome is the complete set of instructions encoded in DNA that makes you who you are. Most technologies cannot read all this information, leading to missing millions of lines of code in this human instruction manual.
Existing sequencing and informatics technologies, if not supplemented by other platforms, cannot capture a complete picture of the dynamic regions in our genome. These huge gaps in knowledge prevent advancements in personalized medicine.
Photo by Awab Husameldin on Unsplash
Solving the Circulome puzzle The next frontier in medicine
Phinomics is spearheading a transformative convergence of biology and AI, pioneering a groundbreaking dataset of novel biomarkers and therapeutic targets in circular DNA to revolutionize precision oncology, target discovery, and drug resistance. This effort has culminated in the Circulome Atlas—a comprehensive, patented dataset mapping circular DNA across diverse tissues, cell types, and pathological conditions.
Our proprietary approach not only identifies new biomarkers and therapeutic targets but also unveils the intricate biological networks underlying cancer and other diseases. This insight opens up new therapeutic pathways and deepens our understanding of cellular mechanisms, enabling more precise interventions.
Founded by experts in DNA biophysics, circular DNA genomics, and data science, Phinomics is backed by rigorous research and cutting-edge innovation. We are leading genomic technologies with a mission to deliver first-in-class circular DNA solutions for urgent healthcare challenges.
The unique, binary nature of circular DNA in our data unlocks new therapeutic approaches, paving the way for precision oncology across multiple cancers and delivering transformative solutions to combat these diseases. Phinomics is poised to shape the future of precision medicine—driving breakthrough discoveries and advancing the frontiers of health.
Circular DNA in Human Cells?!
The human genome is classically depicted as a linear string. However, there exists a subset of the human genome that is circular and is currently missing from any picture we have of our genome. Despite the fact that these circular DNAs drive various pathologies, technological challenges have impeded focused efforts on these elements, which hindered their clinical utility. Our work shows that the repertoire of circular elements or what is now called the circulome varies with disease and pathological state, driving cancer etiology, progression, and drug resistance.
•Unlike linear genes, circular DNA operates outside the constraints of its chromosome, gaining unique “freedoms” to accelerate the propagation of mutations and contribute to drug resistance at a much faster rate in multiple indications and biological systems.
•This behavior, along with the binary prevalence in diseased states, makes circular DNA a uniquely effective set of both biomarkers and therapeutic targets.
Our Technology
Phinomics bridges engineering, data science, and genomic disciplines with immunology and cancer biology to generate unique multi-demential datasets— The Circulome Atlas. We mine these data to enable prediction and treatments of disorders driven by changes in DNA sequence and structure.